Sr. Scientist - Target Discovery

Job Title: Sr. Scientist - Target Discovery
Location: South San Francisco, United States
Reference: 225
Contact Name: Jeff Fisher
Job Published: July 09, 2019 11:11

Job Description

Talent International is partnering with a cutting edge pharmaceutical company in SSF that is looking for a Sr. Scientist – Target Discovery. If you have a passion for bringing novel therapeutics to market and enjoy blending tech and biotech this is the opportunity for you!


Job Description:

    • Lead the validation of multiple, novel targets in ALS, Parkinson’s Disease, and other neurodegenerative diseases in iPSC and in vivo models
    • Triage targets from our proprietary computational platform and prioritize them based on scientific rationale, druggability, risk, and competitive landscape
    • Work cross-functionally with computational biologists, neurobiologists, chemists, intellectual property experts, and business development to make strategic target recommendations
    • Develop clear biological hypotheses for target genes, then establish and validate their mechanism of action (MOA)
    • Propose target genes for experimental prosecution and select appropriate assays to validate each target and the biological hypothesis

Required Experience:

    • 5+ years experience in a drug discovery or industry setting
    • PhD in neuroscience, molecular biology, or related discipline, with 5 years relevant training (neurodegeneration experience preferred)
    • Experience working with genomics, human genetics and next-generation sequencing datasets
    • Experience working collaboratively with computational teams
    • Previous work leading early discovery programs from novel target identification to lead optimization
    • An aptitude to try multiple technologies (i.e. iPSCs, genomics, CRISPR, organoids) or diseases areas

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