Job Search / Research and Development
Sr. Scientist - Target Discovery
Job Details
- Location
- South San Francisco, United States
- Ref
- 225
- Contact
- Jeff Fisher
- Posted
- about 1 month ago
Talent International is partnering with a cutting edge pharmaceutical company in SSF that is looking for a Sr. Scientist – Target Discovery .
Job Description:
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- Lead the validation of multiple, novel targets in ALS, Parkinson’s Disease, and other neurodegenerative diseases in iPSC and in vivo models
- Triage targets from our proprietary computational platform and prioritize them based on scientific rationale, druggability, risk, and competitive landscape
- Work cross-functionally with computational biologists, neurobiologists, chemists, intellectual property experts, and business development to make strategic target recommendations
- Develop clear biological hypotheses for target genes, then establish and validate their mechanism of action (MOA)
- Propose target genes for experimental prosecution and select appropriate assays to validate each target and the biological hypothesis
Required Experience:
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- 5+ years experience in a drug discovery or industry setting
- PhD in neuroscience, molecular biology, or related discipline, with 5 years relevant training (neurodegeneration experience preferred)
- Experience working with genomics, human genetics and next-generation sequencing datasets
- Experience working collaboratively with computational teams
- Previous work leading early discovery programs from novel target identification to lead optimization
- An aptitude to try multiple technologies (i.e. iPSCs, genomics, CRISPR, organoids) or diseases areas